Nkx3-1 - NK3 homeobox 1

Enables several functions, including DNA-binding transcription factor activity; DNA-binding transcription factor binding activity; and MADS box domain binding activity. Involved in protein kinase B signaling; regulation of transcription, DNA-templated; and response to testosterone. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and negative regulation of epithelial cell proliferation involved in prostate gland development. Located in nucleus. Is expressed in several structures, including arterial system; central nervous system; genitourinary system; paraxial mesenchyme; and tooth. Used to study prostate cancer. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human NKX3-1 (NK3 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]