Nin - ninein

Enables microtubule minus-end binding activity. Acts upstream of or within several processes, including generation of neurons; microtubule cytoskeleton organization; and negative regulation of protein localization to centrosome. Located in several cellular components, including axonal growth cone; dendrite; and microtubule cytoskeleton. Part of ciliary transition fiber. Is expressed in several structures, including brain; genitourinary system; gut; limb; and respiratory system. Human ortholog(s) of this gene implicated in Seckel syndrome 7. Orthologous to human NIN (ninein). [provided by Alliance of Genome Resources, Apr 2022]