Nefm - neurofilament, medium polypeptide

Predicted to enable signaling receptor binding activity and toxic substance binding activity. Acts upstream of or within axo-dendritic transport; cytoskeleton organization; and regulation of axon diameter. Located in several cellular components, including intermediate filament cytoskeleton; neuromuscular junction; and postsynaptic density. Is active in presynaptic intermediate filament cytoskeleton. Is expressed in several structures, including alimentary system; branchial arch; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and human immunodeficiency virus infectious disease. Orthologous to human NEFM (neurofilament medium chain). [provided by Alliance of Genome Resources, Apr 2022]