Nfkb1 - nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin binding activity; and identical protein binding activity. Involved in JNK cascade; cellular response to virus; and negative regulation of cytokine production. Acts upstream of or within several processes, including cellular response to dsRNA; cellular response to tumor necrosis factor; and regulation of gene expression. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Apr 2022]