Nfatc1 - nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and mitogen-activated protein kinase p38 binding activity. Involved in heart development and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; branching involved in lymph vessel morphogenesis; and regulation of gene expression. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; eye; genitourinary system; and heart. Orthologous to human NFATC1 (nuclear factor of activated T cells 1). [provided by Alliance of Genome Resources, Apr 2022]