Ncoa3 - nuclear receptor coactivator 3

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II complex binding activity; and nuclear receptor coactivator activity. Involved in cell dedifferentiation; positive regulation of stem cell population maintenance; and regulation of stem cell division. Acts upstream of or within several processes, including mammary gland branching involved in thelarche; negative regulation of stem cell differentiation; and reproductive structure development. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NCOA3 (nuclear receptor coactivator 3). [provided by Alliance of Genome Resources, Apr 2022]