Ncoa2 - nuclear receptor coactivator 2

Enables several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and nuclear receptor coactivator activity. Involved in circadian regulation of gene expression; locomotor rhythm; and regulation of glucose metabolic process. Acts upstream of or within several processes, including cellular response to Thyroglobulin triiodothyronine; regulation of transcription by RNA polymerase II; and response to progesterone. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NCOA2 (nuclear receptor coactivator 2). [provided by Alliance of Genome Resources, Apr 2022]