Ncoa1 - nuclear receptor coactivator 1

Enables DNA binding activity; chromatin binding activity; and transcription coactivator activity. Involved in several processes, including histone H4 acetylation; positive regulation of transcription from RNA polymerase II promoter by galactose; and regulation of cellular response to drug. Acts upstream of or within several processes, including cellular response to Thyroglobulin triiodothyronine; labyrinthine layer morphogenesis; and regulation of thyroid hormone mediated signaling pathway. Predicted to be located in several cellular components, including chromatin; cytosol; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; eye; and genitourinary system. Used to study obesity and thyroid hormone resistance syndrome. Orthologous to human NCOA1 (nuclear receptor coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]