Nck2 - non-catalytic region of tyrosine kinase adaptor protein 2

Enables scaffold protein binding activity. Involved in regulation of cellular macromolecule biosynthetic process and regulation of response to endoplasmic reticulum stress. Acts upstream of or within several processes, including actin filament organization; ephrin receptor signaling pathway; and lamellipodium assembly. Located in vesicle membrane. Is expressed in several structures, including central nervous system; chordamesoderm; gut endoderm; hemolymphoid system gland; and paraxial mesenchyme. Orthologous to human NCK2 (NCK adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]