Myo7a - myosin VIIA

Enables protein domain specific binding activity. Involved in cellular protein localization. Acts upstream of or within several processes, including animal organ morphogenesis; phagolysosome assembly; and pigment granule transport. Located in several cellular components, including melanosome; photoreceptor connecting cilium; and stereocilium base. Is active in stereocilium. Is expressed in central nervous system; liver; sensory organ; and small intestine epithelium. Used to study Usher syndrome type 1 and autosomal recessive nonsyndromic deafness 2. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome (multiple); auditory system disease (multiple); and congenital nystagmus. Orthologous to human MYO7A (myosin VIIA). [provided by Alliance of Genome Resources, Apr 2022]