Myo6 - myosin VI

Predicted to enable actin filament binding activity; identical protein binding activity; and microfilament motor activity. Involved in postsynaptic neurotransmitter receptor internalization and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including cellular response to electrical stimulus; inner ear development; and nervous system development. Located in several cellular components, including brush border; cochlear hair cell ribbon synapse; and glutamatergic synapse. Is active in several cellular components, including Schaffer collateral - CA1 synapse; postsynaptic actin cytoskeleton; and postsynaptic density. Is expressed in ear. Used to study autosomal dominant nonsyndromic deafness 22 and autosomal recessive nonsyndromic deafness 37. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI). [provided by Alliance of Genome Resources, Apr 2022]