Cited2 - Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

Enables several functions, including SMAD binding activity; chromatin binding activity; and transcription coactivator activity. Involved in several processes, including animal organ development; left/right axis specification; and positive regulation of male gonad development. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and embryo development. Located in chromatin and nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; heart; and sensory organ. Used to study tetralogy of Fallot. Human ortholog(s) of this gene implicated in atrial heart septal defect 8 and ventricular septal defect. Orthologous to human CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2). [provided by Alliance of Genome Resources, Apr 2022]