Mpeg1 - macrophage expressed gene 1

Involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and pore formation in membrane of other organism. Located in phagocytic vesicle. Is expressed in several structures, including blood vessel; central nervous system; developing vasculature of reproductive system; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MPEG1 (macrophage expressed 1). [provided by Alliance of Genome Resources, Apr 2022]