Mgmt - O-6-methylguanine-DNA methyltransferase

Enables methyltransferase activity. Acts upstream of or within DNA dealkylation involved in DNA repair and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in embryo and forelimb bud. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; nervous system cancer (multiple); and urinary bladder cancer. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]