Foxc1 - forkhead box C1

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including animal organ development; cell surface receptor signaling pathway; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and vasculature development. Located in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study buphthalmos. Human ortholog(s) of this gene implicated in Axenfeld-Rieger syndrome; Axenfeld-Rieger syndrome type 3; anterior segment dysgenesis 3; and glaucoma. Orthologous to human FOXC1 (forkhead box C1). [provided by Alliance of Genome Resources, Apr 2022]