Mesp2 - mesoderm posterior 2

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including mesodermal cell migration; regulation of gene expression; and somite rostral/caudal axis specification. Located in nucleus. Is expressed in several structures, including central nervous system; ear; embryo mesoderm; genitourinary system; and paraxial mesenchyme. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human MESP2 (mesoderm posterior bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]