Mef2c - myocyte enhancer factor 2C

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and histone deacetylase binding activity. Involved in several processes, including animal organ development; modulation of chemical synaptic transmission; and positive regulation of cell differentiation. Acts upstream of or within several processes, including animal organ development; cardiac muscle hypertrophy in response to stress; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; limb; and urinary system. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 20. Orthologous to human MEF2C (myocyte enhancer factor 2C). [provided by Alliance of Genome Resources, Apr 2022]