Mef2a - myocyte enhancer factor 2A

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including mitochondrion organization; positive regulation of macromolecule metabolic process; and ventricular cardiac myofibril assembly. Acts upstream of or within positive regulation of glucose import and positive regulation of transcription, DNA-templated. Located in chromatin and nucleus. Is expressed in several structures, including brain; cardiovascular system; embryo mesenchyme; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human MEF2A (myocyte enhancer factor 2A). [provided by Alliance of Genome Resources, Apr 2022]