Bub1b - BUB1 mitotic checkpoint serine/threonine kinase B

Predicted to enable protein kinase activity. Predicted to be involved in meiotic sister chromatid cohesion, centromeric and mitotic spindle assembly checkpoint signaling. Predicted to act upstream of or within metaphase/anaphase transition of mitotic cell cycle and protein localization to chromosome, centromeric region. Predicted to be located in cytosol; perinuclear region of cytoplasm; and spindle. Predicted to be part of outer kinetochore. Predicted to colocalize with kinetochore. Human ortholog(s) of this gene implicated in colorectal cancer and mosaic variegated aneuploidy syndrome 1. Orthologous to human BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B). [provided by Alliance of Genome Resources, Apr 2022]