Enables several functions, including Hsp70 protein binding activity; kinesin binding activity; and mitogen-activated protein kinase binding activity. Involved in several processes, including anterograde dendritic transport of messenger ribonucleoprotein complex; positive regulation of long-term synaptic depression; and positive regulation of nervous system development. Located in several cellular components, including cytoplasmic stress granule; dendritic shaft; and nuclear membrane. Part of messenger ribonucleoprotein complex. Used to study microphthalmia. Orthologous to human STAU2 (staufen double-stranded RNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]