Predicted to enable several functions, including SMAD binding activity; signaling receptor binding activity; and transcription regulator inhibitor activity. Involved in heart development; negative regulation of ossification; and positive regulation of pri-miRNA transcription by RNA polymerase II. Acts upstream of or within circulatory system development and ureteric bud development. Predicted to be located in Golgi apparatus; cytosol; and nuclear body. Predicted to be part of heteromeric SMAD protein complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in aortic valve disease 2; craniosynostosis; and radioulnar synostosis. Orthologous to human SMAD6 (SMAD family member 6). [provided by Alliance of Genome Resources, Apr 2022]