Opa1 - OPA1, mitochondrial dynamin like GTPase

Enables kinase binding activity. Involved in several processes, including mitochondrion organization; positive regulation of cellular component organization; and sensory organ development. Located in cytosol. Is extrinsic component of mitochondrial inner membrane. Colocalizes with mitochondrion. Used to study transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); chronic kidney disease; fatty liver disease; ocular hypertension; and rhinitis. Human ortholog(s) of this gene implicated in Behr syndrome; dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; optic atrophy; and optic atrophy 1. Orthologous to human OPA1 (OPA1 mitochondrial dynamin like GTPase). [provided by Alliance of Genome Resources, Apr 2022]