Hrg - histidine-rich glycoprotein

Predicted to enable several functions, including heme binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of endothelial cell migration; and regulation of cellular protein metabolic process. Predicted to act upstream of or within heme export; regulation of transcription from RNA polymerase II promoter in response to iron; and response to organic cyclic compound. Predicted to be located in cell surface and phagolysosome membrane. Predicted to be active in endolysosome and extracellular region. Human ortholog(s) of this gene implicated in thrombophilia due to HRG deficiency and thrombosis. Orthologous to human HRG (histidine rich glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]