Ilk - integrin-linked kinase

Enables SH3 domain binding activity; integrin binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of apoptotic process; nervous system development; and regulation of protein kinase activity. Located in several cellular components, including costamere; dendritic shaft; and focal adhesion. Part of protein-containing complex. Colocalizes with stress fiber. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ILK (integrin linked kinase). [provided by Alliance of Genome Resources, Apr 2022]