Pik3ca - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including positive regulation of smooth muscle cell proliferation; response to dexamethasone; and response to leucine. Part of phosphatidylinositol 3-kinase complex. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast cancer (multiple); cutaneous Paget's disease; and gastrointestinal system cancer (multiple). Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]