Mtdh - metadherin

Predicted to enable NF-kappaB binding activity; double-stranded RNA binding activity; and transcription coactivator activity. Involved in bicellular tight junction assembly. Located in several cellular components, including apical plasma membrane; bicellular tight junction; and intercellular canaliculus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MTDH (metadherin). [provided by Alliance of Genome Resources, Apr 2022]