Tob1 - transducer of ErbB-2.1

Predicted to enable SMAD binding activity; receptor tyrosine kinase binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of cell population proliferation; negative regulation of translation; and regulation of mRNA catabolic process. Predicted to act upstream of or within negative regulation of BMP signaling pathway; negative regulation of osteoblast differentiation; and regulation of SMAD protein signal transduction. Predicted to be part of CCR4-NOT complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human TOB1 (transducer of ERBB2, 1). [provided by Alliance of Genome Resources, Apr 2022]