Crb1 - crumbs family member 1, photoreceptor morphogenesis associated

Predicted to enable calcium ion binding activity. Involved in visual perception. Acts upstream of with a negative effect on cellular protein localization. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; eye morphogenesis; and neurogenesis. Located in several cellular components, including adherens junction; microvillus; and photoreceptor outer segment. Part of subapical complex. Is active in apical part of cell. Is expressed in several structures, including alimentary system; central nervous system; epidermis; genitourinary system; and sensory organ. Used to study Leber congenital amaurosis 8 and retinitis pigmentosa 12. Human ortholog(s) of this gene implicated in pigmented paravenous chorioretinal atrophy and retinal disease (multiple). Orthologous to human CRB1 (crumbs cell polarity complex component 1). [provided by Alliance of Genome Resources, Apr 2022]