Bbc3 - BCL2 binding component 3

Predicted to enable ATPase binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of apoptotic process; and positive regulation of cysteine-type endopeptidase activity. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; and toxin transport. Predicted to be located in mitochondrial envelope. Predicted to be active in mitochondrion. Predicted to colocalize with lysosome. Is expressed in several structures, including central nervous system; immune system; liver; retina; and skeletal muscle. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human BBC3 (BCL2 binding component 3). [provided by Alliance of Genome Resources, Apr 2022]