Otud7a - OTU domain containing 7A

Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and thiol-dependent deubiquitinase. Predicted to be involved in negative regulation of I-kappaB kinase/NF-kappaB signaling and protein deubiquitination. Predicted to act upstream of or within proteolysis. Predicted to be active in cytoplasm and nucleus. Used to study chromosome 15q13.3 microdeletion syndrome. Orthologous to human OTUD7A (OTU deubiquitinase 7A). [provided by Alliance of Genome Resources, Apr 2022]