Hadha - hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

Enables several functions, including hydro-lyase activity; long-chain-3-hydroxyacyl-CoA dehydrogenase activity; and nucleotide binding activity. Involved in fatty acid beta-oxidation and response to xenobiotic stimulus. Located in mitochondrion. Part of mitochondrial fatty acid beta-oxidation multienzyme complex. Biomarker of non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in fatty liver disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]