Nphs2 - nephrosis 2, podocin

Predicted to be involved in actin cytoskeleton reorganization. Located in plasma membrane. Is intrinsic component of the cytoplasmic side of the plasma membrane. Colocalizes with slit diaphragm. Is expressed in liver; metanephros; and ureter. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 2. Orthologous to human NPHS2 (NPHS2 stomatin family member, podocin). [provided by Alliance of Genome Resources, Apr 2022]