Lrp6 - low density lipoprotein receptor-related protein 6

Enables Wnt-protein binding activity; apolipoprotein binding activity; and toxin transmembrane transporter activity. Involved in cell surface receptor signaling pathway involved in cell-cell signaling; positive regulation of neuron projection development; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and regulation of Wnt signaling pathway, planar cell polarity pathway. Located in early endosome and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study fatty liver disease and neural tube defect. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human LRP6 (LDL receptor related protein 6). [provided by Alliance of Genome Resources, Apr 2022]