Lig3 - ligase III, DNA, ATP-dependent

Predicted to enable DNA ligase (ATP) activity. Involved in double-strand break repair via alternative nonhomologous end joining and mitochondrion organization. Acts upstream of or within double-strand break repair via nonhomologous end joining; mitochondrial DNA repair; and negative regulation of DNA recombination. Located in synaptonemal complex. Is expressed in several structures, including early conceptus; gonad; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human LIG3 (DNA ligase 3). [provided by Alliance of Genome Resources, Apr 2022]