Krt6a - keratin 6A

Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-positive bacterium; and wound healing. Acts upstream of or within Wnt signaling pathway; intermediate filament organization; and keratinization. Predicted to be located in keratin filament. Is expressed in alimentary system; epithelium; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in pachyonychia congenita. Orthologous to several human genes including KRT6A (keratin 6A). [provided by Alliance of Genome Resources, Apr 2022]