Kras - Kirsten rat sarcoma viral oncogene homolog

Enables GTPase activity. Involved in endocrine signaling. Acts upstream of or within several processes, including forebrain astrocyte development; modulation of chemical synaptic transmission; and positive regulation of Rac protein signal transduction. Located in membrane. Is expressed in several structures, including brain; early embryo; eye; genitourinary system; and gut. Used to study several diseases, including Noonan syndrome 3; carcinoma (multiple); juvenile myelomonocytic leukemia; lung cancer; and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]