Klf4 - Kruppel-like factor 4 (gut)

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity; and beta-catenin binding activity. Involved in several processes, including canonical Wnt signaling pathway; positive regulation of core promoter binding activity; and transcription, DNA-templated. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of blastocyst development; and regulation of transcription, DNA-templated. Located in cytoplasm; euchromatin; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; limb; and skin. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human KLF4 (Kruppel like factor 4). [provided by Alliance of Genome Resources, Apr 2022]