Kl - klotho

Enables fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Acts upstream of or within several processes, including calcium ion homeostasis; energy reserve metabolic process; and positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be integral component of membrane. Is expressed in brain. Used to study hyperphosphatemic familial tumoral calcinosis and pulmonary emphysema. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho). [provided by Alliance of Genome Resources, Apr 2022]