Jag1 - jagged 1

Enables Notch binding activity. Involved in several processes, including circulatory system development; glomerular visceral epithelial cell development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including animal organ development; negative regulation of cell differentiation; and positive regulation of cell differentiation. Located in adherens junction and apical plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study Alagille syndrome. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1). [provided by Alliance of Genome Resources, Apr 2022]