Enables integrin binding activity. Involved in integrin-mediated signaling pathway; stress fiber assembly; and transforming growth factor beta receptor signaling pathway. Located in cell leading edge; focal adhesion; and glutamatergic synapse. Is integral component of synaptic membrane. Part of integrin alphav-beta5 complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and genitourinary system. Orthologous to human ITGB5 (integrin subunit beta 5). [provided by Alliance of Genome Resources, Apr 2022]