Itgb3 - integrin beta 3

Enables integrin binding activity and protein kinase C binding activity. Involved in several processes, including positive regulation of T cell migration; positive regulation of osteoblast proliferation; and regulation of serotonin uptake. Acts upstream of or within several processes, including cellular response to platelet-derived growth factor stimulus; positive regulation of cell-substrate adhesion; and positive regulation of fibroblast migration. Located in several cellular components, including external side of plasma membrane; focal adhesion; and glutamatergic synapse. Part of alpha9-beta1 integrin-ADAM8 complex and alphav-beta3 integrin-PKCalpha complex. Is integral component of synaptic membrane. Is expressed in several structures, including bladder; dorsal aorta; gut; liver; and lung. Used to study Glanzmann's thrombasthenia and platelet-type bleeding disorder 16. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Orthologous to human ITGB3 (integrin subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]