Itga4 - integrin alpha 4

Enables fibronectin binding activity. Acts upstream of or within several processes, including chorio-allantoic fusion; face development; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in cell-cell junction and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in autism spectrum disorder and pancreatic cancer. Orthologous to human ITGA4 (integrin subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]