Isl1 - ISL1 transcription factor, LIM/homeodomain

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; promoter-specific chromatin binding activity; and sequence-specific DNA binding activity. Involved in several processes, including heart development; nervous system development; and positive regulation of cytokine production. Acts upstream of or within several processes, including animal organ development; neuron development; and positive regulation of nitrogen compound metabolic process. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and heart and pericardium. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human ISL1 (ISL LIM homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]