Irx3 - Iroquois related homeobox 3

Enables DNA-binding transcription activator activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including His-Purkinje system development; energy homeostasis; and regulation of transcription by RNA polymerase II. Acts upstream of or within kidney development; mesoderm development; and regulation of neuron differentiation. Located in axon; cytoplasm; and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart; limb; and sensory organ. Orthologous to human IRX3 (iroquois homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]