Ilk - integrin linked kinase

Predicted to enable several functions, including SH3 domain binding activity; integrin binding activity; and protein kinase binding activity. Involved in outflow tract morphogenesis; positive regulation of BMP signaling pathway; and positive regulation of osteoblast differentiation. Acts upstream of or within several processes, including fibroblast migration; nervous system development; and protein kinase B signaling. Located in focal adhesion and lamellipodium. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and retina. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ILK (integrin linked kinase). [provided by Alliance of Genome Resources, Apr 2022]