Enables GTPase activity. Acts upstream of or within cellular response to interferon-beta. Located in cytosol. Is expressed in alimentary system; hemolymphoid system; liver; thymus primordium; and tongue. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M). [provided by Alliance of Genome Resources, Apr 2022]