Enables double-stranded DNA binding activity and transcription coregulator activity. Involved in cellular response to interferon-alpha. Acts upstream of or within several processes, including cellular response to interferon-beta; inner ear development; and positive regulation of osteoblast differentiation. Located in nuclear inclusion body and nucleolus. Is expressed in esophagus; male reproductive gland or organ; and tibia. Orthologous to human IFI16 (interferon gamma inducible protein 16). [provided by Alliance of Genome Resources, Apr 2022]