Irgm1 - immunity-related GTPase family M member 1

Predicted to enable several functions, including GTPase activity; protein domain specific binding activity; and protein serine/threonine kinase activator activity. Involved in several processes, including positive regulation by symbiont of host autophagy; positive regulation of autophagosome maturation; and positive regulation of interferon-gamma-mediated signaling pathway. Acts upstream of or within cellular response to interferon-gamma and response to bacterium. Located in autolysosome; late endosome; and phagocytic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M). [provided by Alliance of Genome Resources, Apr 2022]