Idh1 - isocitrate dehydrogenase 1 (NADP+), soluble

Enables isocitrate dehydrogenase (NADP+) activity. Acts upstream of or within glutathione metabolic process; regulation of phospholipid metabolic process; and response to oxidative stress. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Apr 2022]