Ide - insulin degrading enzyme

Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and peptide binding activity. Involved in insulin catabolic process. Acts upstream of or within amyloid-beta clearance and response to oxidative stress. Located in extracellular exosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme). [provided by Alliance of Genome Resources, Apr 2022]